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KMID : 0624620160490020128
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BMB Reports
2016 Volume.49 No. 2 p.128 ~ p.133
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Epac2 contributes to PACAP-induced astrocytic differentiation through calcium ion influx in neural precursor cells
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Seo Hyun-Hyo
Lee Kyung-Min
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Abstract
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Astrocytes play a critical role in normal brain functions and maintaining the brain microenvironment, and defects in astrocytogenesis during neurodevelopment could give rise to severe mental illness and psychiatric disorders. During neuro- embryogenesis, astrocytogenesis involves astrocytic differentiation of neural precursor cells (NPCs) induced by signals from ciliary neurotrophic factor (CNTF) or pituitary adenylate cyclase-activating peptide (PACAP). However, in contrast to the CNTF signaling pathway, the exact mechanism underlying astrocytic differentiation induced by PACAP is unknown. In the present study, we aimed to verify a signaling pathway specific to PACAP-induced astrocytogenesis, using exchange protein directly activated by cAMP2 (Epac2)-knockout mice. We found that PACAP could trigger astrocytic differentiation of NPCs via Epac2 activation and an increase in the intracellular calcium concentration via a calcium ion influx. Taken together, we concluded that astrocytogenesis stimulated by PACAP occurs through a novel signaling pathway independent from CNTF-JAK/STAT signaling, that is the well-known pathway of astrocytogenesis.
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KEYWORD
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Astrocytogenesis, Calcium ion, Exchange protein directly activated by cAMP2 (Epac2), Neural precursor cells (NPCs), Pituitary adenylate cyclase-activating peptide (PACAP)
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